La phrase « Losing My Religion » est une expression des régions du sud des États-Unis qui signifie perdre son tempérament, perdre son calme. Lors d'une interview au New York Times Stipe a dit que la chanson relatait l'histoire de « quelqu'un qui désire quelqu'un d'autre. C'est un amour non réciproque. » Il compare le thème de la chanson à celui de Every Breath You Take du groupe The Police, car selon lui « C'est juste une chanson pop avec une obsession classique. Je me suis toujours dit que les meilleures chansons sont celles que tout le monde peut écouter, se projeter dedans et dire, « Oui, c'est moi. »
Losing My Religion est une chanson du groupe de rock alternatif américain R.E.M., extrait de l'album Out of Time, sortie en 1991. Basée sur un riff de mandoline, Losing My Religion est le plus gros succès du groupe, obtenant de nombreuses diffusions radiophoniques et télévisées sur MTV, grâce à un clip vidéo salué par la critique.

Oh, life is bigger
It's bigger
Than you and you are not me
The lengths that I will go to
The distance in your eyes
Oh no, I've said too much
I set it up
That's me in the corner
That's me in the spotlight
Losing my religion
Trying to keep up with you
And I don't know if I can do it
Oh no, I've said too much
I haven't said enough
I thought that I heard you laughing
I thought that I heard you sing
I think I thought I saw you try
Every whisper
Of every waking hour
I'm choosing my confessions
Trying to keep an eye on you
Like a hurt lost and blinded fool, fool
Oh no, I've said too much
I set it up
Consider this
Consider this
The hint of the century
Consider this
The slip that brought me
To my knees failed
What if all these fantasies
Come flailing around
Now I've said too much
I thought that I heard you laughing
I thought that I heard you sing
I think I thought I saw you try
But that was just a dream
That was just a dream
That's me in the corner
That's me in the spotlight
Losing my religion
Trying to keep up with you
And I don't know if I can do it
Oh no, I've said too much
I haven't said enough
I thought that I heard you laughing
I thought that I heard you sing
I think I thought I saw you try
But that was just a dream
Try, cry
Why try?
That was just a dream, just a dream, just a dream
Dream